Roy Dar

For more information

• Dar Lab Website

Education

• Ph.D. Physics, University of Tennessee, Knoxville (2011)
• B.Sc. Physics and Mathematics, Hebrew University of Jerusalem, Israel (2004)

Academic Positions

• Assistant Professor, University of Illinois at Urbana-Champaign, Department of Bioengineering, 2015-Present
• Affiliate Faculty, Department of Electrical and Computer Engineering, 2018-Present
• Affiliate Faculty, Carl R. Woese Institute for Genomic Biology, 2015-Present
• Affiliate Faculty, Cancer Center at Illinois, 2017-Present
• Affiliate Faculty, Center for Biophysics and Quantitative Biology, 2015-Present
• Postdoctoral Fellow, Gladstone Institutes, University of California, San Francisco, 2011-2015

Research Interests

• Drug Screening
• Cellular Fate-Determination and State Transitions
• Viral and Genetic Circuitry
• Stochastic Gene Expression
• Single-Cell Biophysics
• Systems Biology

Research Topics

• Genomics

Chapters in Books

• ML Simpson, CD Cox, MS Allen, JM McCollum, RD Dar, DK Karig, and JF Cooke (2009) Noise in Biological Circuits. In WIREs Nanomed Nanobiotechnol 1: 214–225

Selected Articles in Journals

• CD Cox, JM McCollum, DW Austin, MS Allen, RD Dar, and ML Simpson (2006) Frequency domain analysis of noise in simple gene circuits. Chaos 16:026102.
• DW Austin, MS Allen, JM McCollum, RD Dar, JR Wilgus, GS Sayler, NF Samatova, CD Cox, and ML Simpson (2006) Gene network shaping of inherent noise spectra. Nature 439:608–11.
• CD Cox, JM McCollum, MS Allen, RD Dar, and ML Simpson (2008) Using noise to probe and characterize gene circuits. Proc Nat Acad Sci USA 105:10809–10814.
• LS Weinberger*, RD Dar*, and ML Simpson (2008) Transient mediated fate-determination in a transcriptional circuit of HIV. Nature Genetics 40:466–470. (* - equal contribution)
• RD Dar, DK Karig, JF Cooke, CD Cox, and ML Simpson (2010) Distribution and regulation of stochasticity and plasticity in Saccharomyces cerevisiae. Chaos 20:037106.
• DK Karig, P Siuti, RD Dar, ST Retterer, MJ Doktycz, and ML Simpson (2011) Model for biological communication in a nanofabricated cell-mimic driven by stochastic resonance. Nano Comm Net 2:39–49.
• A Singh, BS Razooky, RD Dar, and LS Weinberger (2012) Dynamics of protein noise can distinguish between alternative sources of gene-expression variability. Mol Syst Biol 8:607.
• RD Dar*, BS Razooky*, A Singh, TV Trimeloni, JM McCollum, CD Cox, ML Simpson, and LS Weinberger (2012) Transcriptional burst frequency and burst size are equally modulated across the human genome. Proc Na. Acad Sc. USA 109:17454–17459. (* - equal contribution)
• MW Teng*, C Bolovan-Fritts*, RD Dar, A Womack, T Shenk, ML Simpson, and LS Weinberger (2012) An endogenous accelerator for viral gene expression provides a fitness advantage. Cell 151:1569–1580. (* - equal contribution)
• D Boehm, V Calvanese, RD Dar, S Xing, S Schroeder, L Martins, K Aull, P Li, V Planelles, JE Bradner, M Zhou, RF Siliciano, LS Weinberger, E Verdin, and M Ott (2012) BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle 2:452–462.
• RD Dar, NN Hosmane, MR Arkin, RF Siliciano, and LS Weinberger (2014) Screening for noise in gene expression identifies drug synergies. Science 44:1392–1396.
• RD Dar, BS Razooky, LS Weinberger, CD Cox, and ML Simpson (2015) The Low Noise Limit in Gene Expression. PLoS ONE 10(10): e0140969
• RD Dar**, SM Shaffer, A Singh, BS Razooky, ML Simpson, A Raj, and LS Weinberger (2016) Transcriptional Bursting Explains the Noise-Versus-Mean Relationship in mRNA and Protein Levels. PLoS ONE 11(7): e0158298. (**Corr. Author)
• K Bohn-Wippert, EN Tevonian, MR Megaridis, and RD Dar (2017) Similarity in viral and host promoters couples viral reactivation with host cell migration. Nature Communications 8:15006. doi:10.1038/ncomms15006
• MR Megaridis*, Y Lu*, EN Tevonian, KM Junger, JM Moy, K Bohn-Wippert, and RD Dar (2018) Fine-Tuning of Noise in Gene Expression with Nucleosome Remodeling. APL Bioengineering. 2:026106. doi:10.1063/1.5021183 . (* - equal contribution)
• RD Dar and R Weiss (2018) Engineering noise in biological systems towards predictive stochastic design. APL Bioengineering. 2:020901. doi:10.1063/1.5025033.
• MMK Hansen*, WY Wen*, E Ingerman*, BS Razooky, CE Thompson, RD Dar, CW Chin, ML Simpson, and LS Weinberger (2018) A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization. Cell 173:1-13 (* - equal contribution)
• RD Kamm, R Bashir, N Arora, RD Dar, LG Griffith, ML Kemp, K Kinlaw, M Levin, AC Martin, TC McDevitt, RM Nerem, M Powers, TA. Saif, J Sharpe, S Takayama, S Takeuchi, R Weiss, K Ye, HG Yevick, and M Zaman (2018) The promise of multi-cellular engineered living systems. APL Bioengineering 2:040901. doi.org/10.1063/1.5038337
• K Bohn-Wippert*, EN Tevonian*, Y Lu, M-Y Huang, MR Megaridis, and RD Dar (2018) Cell size-based decision-making of a viral gene circuit. Cell Reports 25:3844-3857. doi.org/10.1016/j.celrep.2018.12.009 (* - equal contribution)
• K Bohn-Wippert and RD Dar (2020) Cell size dependent migration of T-cells latently infected with HIV. Journal of Life Sciences 2:1
• T Mahajan and RD Dar (2021) Internetwork connectivity of molecular networks across species of life. Scientific Reports 11:1168
• Y Lu, A Singh, and RD Dar (2021) A transient heritable memory regulates HIV reactivation from latency. iScience https://doi.org/10.1016/j.isci.2021.102291
• Y Lu, K Bohn-Wippert, PJ Pazerunas, JM Moy, H Singh, and RD Dar (2021) Screening for gene expression fluctuations reveals latency promoting agents of HIV. Proc Na. Acad Sc. USA 118 (11) e2012191118
• N Goswami, Y Lu, ME Kandel, MJ Fanous, K Bohn-Wippert, EN Tevonian, RD Dar, and G Popescu (2020) Monitoring Reactivation of Latent HIV by Label-Free Gradient Light Interference Microscopy. bioRxiv
• A Blanco, T Mahajan, RA Coronado, K Ma, DR Demma, and RD Dar (2021) Synergistic Chromatin-Modifying Treatments Reactivate Latent HIV and Decrease Migration of Multiple Host-Cell Types. Viruses 13(6), 1097.

Honors

• NSF CAREER Award (2020)
• NIBIB Trailblazer Award for New and Early Stage Investigators, NIH (2018)
• Innovation Lab Award, The Jayne Koskinas Ted Giovanis Foundation (2018)
• Scialog Fellow, Gordon and Betty Moore Foundation with Rescorp (2017)
• NIH Career Transition Award (K22), NIAID, NIH (2015)
• Gordon Research Conference Best Poster Award, Ventura, CA (2015)
• Postdoctoral Award for Exemplary Leadership, Gladstone Institutes, UCSF (2015)
• Postdoctoral Award for Scientific Excellence, Gladstone Institutes, UCSF (2014)
• Ruth L. Kirschstein National Research Service Award (NRSA, F32), NIAID, NIH (2012)
• Paul H. Stelson Fellowship for Professional Promise, University of Tennessee (2011)
• Sigma Pi Sigma, National Physics Honors Society, University of Tennessee Chapter (2008-2011)

Teaching Honors

• Teaching Excellence Award, Illinois Student Government, UIUC (4/22/2018)

Research Honors

• The Jayne Koskinas Ted Giovanis Foundation "Innovation Lab Award" (7/24/2018)
• Rescorp and Gordon and Betty Moore Foundation "Scialog Collaborative Innovation Award" (7/26/2017)

Courses Taught

• BIOE 206 - Cellular Bioengineering
• BIOE 310 - Comp Tools Bio Data
• BIOE 487 - Stem Cell Bioengineering
• BIOE 497 - Individual Study
• BIOE 598 - Single-Cell Decision-Making
• BIOE 598 - Stem Cell Bioengineering