Pengfei Song

Electrical and Computer Engineering
Pengfei Song
Adjunct Assistant Professor

Primary Research Area

  • Biomedical Imaging, Bioengineering, and Acoustics

For more information

Profile

Education

  • Ph.D. in Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, MN, 2014
  • M.S. in Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE, 2010
  • B.S. in Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, China, 2008

Biography

Dr. Pengfei Song is an incoming Assistant Professor of the Department of Electrical and Computer Engineering and the Beckman Institute. He was previously an Assistant Professor and Associate Consultant in the Department of Radiology at Mayo Clinic. His research interests mainly focus on ultrasound microvessel imaging and ultrasound shear wave elastography. Dr. Song has published over 40 peer-reviewed journal papers on topics of ultrasound shear wave elastography, ultrafast microvessel imaging, and super-resolution microvessel imaging. Dr. Song holds several patents that have been licensed and commercialized by major ultrasound companies, installed on top-tier ultrasound scanners and used worldwide to benefit patients. Dr. Song is an awardee of the American Heart Association postdoctoral fellowship and the NIH K99/R00 Pathway to Independence Award.

Research Interests

  • Ultrafast ultrasound imaging
  • Super-resolution ultrasound microvessel imaging
  • Ultrasound elastography
  • Ultrasound beamforming and signal processing
  • Functional ultrasound imaging

Research Areas

Selected Articles in Journals

  • Zhao H, Song P, Urban MW, Kinnick RR, Yin M, Greenleaf JF, Chen S, “Bias Observed in Time-of-flight Shear Wave Speed Measurements Using Radiation Force of a Focused Ultrasound Beam”, Ultrasound in Medicine and Biology, vol. 37, no. 11, pp. 1884 – 1892, 2011.
  • Zhao H, Song P, Urban MW, Greenleaf JF, Chen S, “Shear Wave Speed Measurement Using an Unfocused Ultrasound Beam”, Ultrasound in Medicine and Biology, vol. 38, no. 9, pp. 1646 – 1655, 2012.
  • Song P, Zhao H, Manduca A, Urban MW, Greenleaf JF, Chen S, “Comb-push Ultrasound Shear Elastography (CUSE): A Novel Method for Two-dimensional Shear Elasticity Imaging of Soft Tissues”, IEEE Transactions on Medical Imaging, vol. 31, issue 9, pp. 1821 – 1832, 2012.
  • Eby SF, Song P, Chen S, Chen Q, Greenleaf JF, An KN, “Validation of Shear Wave Elastography in Skeletal Muscle”, Journal of Biomechanics, vol. 46, issue 14, pp. 2381-2387, 2013.
  • Kulig K, Robert L, Chang YJ, Hannanvash N, Reischl SF, Song P, Bashford GR, “Patellar Tendon Morphology in Volleyball Athletes with and without Patellar Tendinopathy”, Scandinavian Journal of Medicine and Science in Sports, 23(2): e81-8, 2013.
  • Song P, Zhao H, Urban MW, Manduca A, Pislaru SV, Kinnick RR, Pislaru C, Greenleaf JF, Chen S, “Improved Shear Wave Motion Detection Using Pulse-Inversion Harmonic Imaging with a Phased Array Transducer”, IEEE Transactions on Medical Imaging, vol. 32, issue 12, pp. 2299-2310, 2013.
  • Song P, Urban MW, Manduca A, Zhao H, Greenleaf JF, Chen S, “Comb-push Ultrasound Shear Elastography (CUSE) with Various Ultrasound Push Beams”, IEEE Transactions on Medical Imaging, vol. 32, issue 8, pp. 1435 – 1447, 2013.
  • Song P, Manduca A, Zhao H, Urban MW, Greenleaf JF, Chen S, “Fast Shear Compounding Using Robust 2-D Shear Wave Speed Calculation and Multi-directional Filtering”, Ultrasound in Medicine and Biology, vol. 40, no. 6, pp. 1343-1355, 2014.
  • Brandenburg JE, Eby SF, Song P, Zhao H, Brault JS, Chen S, An KN, “Ultrasound Elastography: The New Frontier in Direct Measurement of Muscle Stiffness”, Archives of Physical Medicine and Rehabilitation, vol. 95, issue 11, pp. 2207 – 2219, 2014.
  • Zhao H, Song P, Meixner DD, Kinnick RR, Callstrom MR, Sanchez W, Urban MW, Manduca A, Greenleaf JF, Chen S, “External Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE): Application in Liver Fibrosis Staging”, IEEE Transactions on Medical Imaging, vol. 33, issue. 11, pp. 2140 – 2148, 2014. (Journal featured article)
  • Dillman JR, Chen S, Zhao H, Urban MW, Song P, Larson ED, Watcharotone K, Davenport MS, Carson PL, “Superficial ultrasound shear wave speed measurements in soft and hard elasticity phantoms: repeatability and reproducibility using two ultrasound systems”, Pediatric Radiology, pp. 1 – 10, 2014.
  • Mehrmohammadi M, Song P, Meixner DD, Fazzio RT, Callstrom MR, Chen S, Fatemi M, Alizad A, “Comb-push Ultrasound Shear Elastography (CUSE) for Evaluation of Thyroid Nodules: Preliminary In Vivo Results,” IEEE Transactions on Medical Imaging, vol. 34, no. 1, pp. 97 – 106, 2015.
  • Eby SF, Cloud BA, Brandenburg JE, Giambini H, Song P, Chen S, LeBrasseur NK, An KN, “Shear Wave Elastography of Passive Skeletal Muscle Stiffness: Influences of Sex and Age throughout Adulthood,” Clinical Biomechanics, vol. 30, issue 1, pp. 22 – 27, 2015.
  • Nabavizadeh A, Song P, Chen S, Greenleaf JF, Urban MW, “Multi-Source and Multi-Directional Shear Wave Generation with Intersecting Steered Ultrasound Push Beams,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 62, no. 4, pp. 647-662, 2015. (Journal cover)
  • Song P, Macdonald MC, Behler RH, Lanning JD, Wang MH, Urban MW, Manduca A, Zhao H, Callstrom MR, Alizad A, Greenleaf JF, Chen S, “Two-dimensional Shear Wave Elastography on Conventional Ultrasound Scanners with Time Aligned Sequential Tracking (TAST) and Comb-push Ultrasound Shear Elastography (CUSE),” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 62, issue 2, pp. 290 – 302, 2015. (Journal cover)
  • Brandenburg JE, Eby SF, Song P, Zhao H, Landry BW, Chen S, Sieck GC, An KN, “Feasibility and Reliability of Quantifying Passive Muscle Stiffness in Young Children Using Ultrasound Shear Wave Elastography,” Journal of Ultrasound in Medicine, vol. 34, no. 4, pp. 663-670, 2015.
  • Itoigawa Y, Sperling JW, Steinmann SP, Chen Q, Song P, Chen S, Itoi E, Hatta T, An KN, “Feasibility Assessment of Shear Wave Elastography to Rotator Cuff Muscle,” Clinical Anatomy, vol. 28, issue 2, pp. 213-218, 2015.
  • Denis M, Mehrmohammadi M, Song P, Meixner DD, Fazzio RT, Pruthi S, Chen S, Fatemi M, Alizad A, “Comb-push Ultrasound Shear Elastography of Breast Masses: Initial Results Show Promise,” PLoS ONE, 10(3): e0119398, 2015.
  • Song P, Urban MW, Manduca A, Greenleaf JF, Chen S, “Coded Excitation Plane Wave Imaging for Shear Wave Motion Detection,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 62, no. 7, pp. 1356-1372, 2015.
  • Denis M, Bayat M, Mehrmohammadi M, Gregory A, Song P, Whaley DH, Pruthi S, Chen S, Fatemi M, Alizad A, “Update on Breast Cancer Detection Using Comb-push Ultrasound Shear Elastography,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 62, no. 9, pp. 1644-1650, 2015.
  • Song P, Mellema DC, Sheedy SP, Meixner DD, Karshen RM, Urban MW, Manduca A, Sanchez W, Callstrom MR, Greenleaf, JF, Chen S, “Performance of 2-Dimensional Ultrasound Shear Wave Elastography in Liver Fibrosis Detection Using Magnetic Resonance Elastography as the Reference Standard: A Pilot Study,” Journal of Ultrasound in Medicine, vol. 35, no. 2, pp. 401-412, 2016.
  • Song P, Bi X (co-first author), Mellema DC, Manduca A, Urban MW, Greenleaf JF, Chen S, “Quantitative Assessment of Left Ventricular Diastolic Stiffness Using Cardiac Shear Wave Elastography: A Pilot Study,” Journal of Ultrasound in Medicine, vol. 35, pp. 1419-1427, 2016.
  • Urban MW, Qiang B, Song P, Nenadic IZ, Chen S, Greenleaf JF, “Investigation of the Effects of Myocardial Anisotropy for Shear Wave Elastography Using Impulsive Force and Harmonic Vibration,” Physics in Medicine and Biology, vol. 61, no. 1, pp. 365-382, 2016.
  • Amador Carrascal C, Song P, Meixner DD, Chen S, Urban MW, “Improvement of Shear Wave Motion Detection Using Harmonic Imaging in Healthy Human Liver,” Ultrasound in Medicine and Biology, vol. 42, no. 5, pp. 1031-1041, 2016.
  • Eby SF, Zhao H, Song P, Vareberg BJ, Kinnick RR, Greenleaf JF, An KN, Chen S, Brown AW, “Quantitative Evaluation of Passive Muscle Stiffness in Chronic Stroke,” American Journal of Physical Medicine and Rehabilitation, vol. 95, issue 12, pp. 899-910, 2016.
  • Song P, Bi X, Mellema DC, Manduca A, Urban MW, Pellikka PA, Chen S, Greenleaf JF, “Pediatric Cardiac Shear Wave Elastography for Quantitative Assessment of Myocardial Stiffness: A Pilot Study in Healthy Controls,” Ultrasound in Medicine and Biology, vol. 42, issue 8, pp. 1719-1729, 2016.
  • Mellema DC, Song P, Kinnick RR, Urban MW, Greenleaf JF, Manduca A, Chen S, “Probe Oscillation Shear Elastography (PROSE): A High Frame-Rate Method for Two-Dimensional Ultrasound Shear Wave Elastography,” IEEE Transactions on Medical Imaging, vol. 35, no. 9, pp. 2098-2106, 2016.
  • Brandenburg JE, Eby SF, Song P, Bamlet WR, Kingsley-Berg SM, Sieck GS, An KN, “Quantifying Passive Muscle Stiffness in Children with and without Cerebral Palsy Using Shear Wave Elastography,” Developmental Medicine and Child Neurology, vol. 58, issue 12, pp. 1288-1294, 2016.
  • Song P, Manduca A, Trzasko JD, Chen S, “Ultrasound Small Vessel Imaging with Block-wise Adaptive Local Clutter Filtering,” IEEE Transactions on Medical Imaging, vol. 36, no. 1, pp. 251-262, 2017.
  • Gong P, Song P, Chen S, “Delay-encoded Harmonic Imaging (DE-HI) in Multiplane-wave Compounding,” IEEE Transactions on Medical Imaging, vol. 36, no. 4, pp. 952-959, 2017.
  • Eby SF, Zhao H, Song P, Vareberg BJ, Kinnick RR, Greenleaf JF, An KN, Brown AW, Chen S, “Quantifying Spasticity in Individual Muscles Using Shear Wave Elastography,” Radiology Case Reports, vol. 12, issue 2, pp. 348-352, 2017.
  • Song P, Trzasko JD, Manduca A, Qiang B, Kadirvel R, Kallmes DF, Chen S, “Accelerated Singular Value-Based Ultrasound Blood Flow Clutter Filtering with Randomized Singular Value Decomposition (rSVD) and Randomized Spatial Downsampling,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 64, no. 4, pp. 706-716, 2017.
  • Gong P, Song P, Chen S, “Ultrafast Synthetic Transmit Aperture Imaging (USTA) Using Hadamard-Encoded Virtual Sources with Overlapping Sub-Apertures,” IEEE Transactions on Medical Imaging, vol. 36, no. 6, pp. 1372-1381, 2017.
  • Song P, Manduca A, Trzasko JD, Chen S, “Letters: Noise Equalization for Ultrafast Plane Wave Microvessel Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 64, issue 11, pp. 1776-1781, 2017.
  • Gong P, Song P, Chen S, “Hadamard Encoded Multi-Pulses for Contrast Enhanced Ultrasound Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 64, issue 11, pp. 1674-1683, 2017.
  • Mellema DC, Song P, Manduca A, Urban MW, Kinnick RR, Greenleaf JF, Chen S, “Probe Oscillation Shear Wave Elastography: Initial In Vivo Results in Liver,” IEEE Transactions on Medical Imaging, vol. 37, no. 5, pp. 1214-1223, 2018.
  • Gong P, Song P, Chen S, “Improved Contrast Enhanced Ultrasound Imaging with Multiplane Wave Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 65, issue 2, pp. 178-187, 2018.
  • Song P, Trzasko JD, Manduca A, Huang R, Kadirvel R, Kallmes DF, Chen S, “Improved Super-Resolution Ultrasound Microvessel Imaging with Spatiotemporal Nonlocal Means Filtering and Bipartite Graph-Based Microbubble Tracking,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 65, issue 2, pp. 149-167, 2018. (Journal cover)
  • Long Z, Tradup DJ, Song P, Stekel SF, Chen S, Glazebrook KN, Hangiandreou NJ, “Clinical Acceptance Testing and Scanner Comparison of Ultrasound Shear Wave Elastography,” Journal of Applied Clinical Medical Physics, vol. 19, issue 3, pp. 336-342, 2018.
  • Kijanka P, Qiang B, Song P, Amador Carrascal C, Chen S, Urban MW, “Robust Phase Velocity Dispersion Estimation of Viscoelastic Materials Used for Medical Applications Based on the Multiple Signal Classification Method,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 65, issue 3, pp. 423-439, 2018.
  • Liu X, Gong P, Song P, Xie F, Miller AL, Chen S, Lu L, “Fast Functionalization of Ultrasound Microbubbles Using Strain Promoted Click Chemistry,” Biomaterials Science, vol. 6, issue 3, pp. 623-632, 2018.
  • Brandenburg JE, Eby SF, Song P, Bamlet WR, Sieck GC, An KN, “Quantifying Effect of Onabotulinum Toxin A on Passive Muscle Stiffness in Children with Cerebral Palsy Using Ultrasound Shear Wave Elastography,” American Journal of Physical Medicine and Rehabilitation, vol. 97, issue 7, pp. 500-506, 2018.
  • Song P, Manduca A, Trzasko JD, Daigle RE, Chen S, “On the Effects of Spatial Sampling Quantization in Super-Resolution Ultrasound Microvessel Imaging,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control (in press).
  • Gong P, Song P, Chen S, “On Combination of Hadamard-encoded Multi-pulses (HEM) and Multiplane Wave (MW) Transmission in Contrast Enhanced Ultrasound Imaging”, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control (in press).

Honors

  • Edward C. Kendall Alumni Award for Meritorious Research, Mayo Clinic Alumni Association (2018)
  • Introduction to Academic Radiology for Scientists (ITARSc) Program, Radiological Society of North America (November, 2017)

Research Honors

  • NIH K99/R00 Pathway to Independence Award (2017-2022)
  • American Heart Association Postdoctoral Fellowship (2014-2016)