Aiguo Han

Electrical and Computer Engineering
Aiguo Han
Research Assistant Professor
2058 ECE Building
306 North Wright Street
Urbana Illinois 61801

Primary Research Area

  • Biomedical Imaging, Bioengineering, and Acoustics

Profile

Education

  • Ph.D. in Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 2014
  • M.S. in Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 2011
  • B.S. in Acoustics, Nanjing University, 2008

Research Interests

  • Machine learning
  • Quantitative imaging biomarkers
  • Quantitative ultrasound imaging
  • Ultrasonic wave propagation in biological media

Research Areas

Research Topics

  • Healthcare and medical technologies
  • Imaging science and systems
  • Medical imaging

Selected Articles in Journals

  • A. Han, Y. N. Zhang, A. S. Boehringer, M. P. Andre, J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and W. D. O’Brien, Jr., “Inter-platform reproducibility of ultrasonic attenuation and backscatter coefficients in assessing NALFD,” Eur. Radiol., doi: 10.1007/s00330-019-06035-9.
  • R. J. Miller, A. Han, J. W. Erdman, Jr., M. A. Wallig, W. D. O’Brien, Jr., “Quantitative ultrasound and the pancreas: Demonstration of early detection capability,” J. Ultrasound Med., doi: 10.1002/jum.14901. [Epub ahead of print]
  • J. L. Rowles, A. Han, R. J. Miller, J. R. Kelly, C. C. Applegate, M. A. Wallig, W. D. O’Brien, Jr., and J. W. Erdman, Jr., “Low fat but not soy protein isolate was an effective intervention to reduce nonalcoholic fatty liver disease progression in C57BL/6J mice: monitored by a novel quantitative ultrasound (QUS) method,” Nutr. Res., vol. 63, pp. 95–105, 2019.
  • A. Han, Y. Labyed, E. Z. Sy, A. S. Boehringer, M. P. Andre, J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and W. D. O’Brien, Jr., “Inter-sonographer reproducibility of quantitative ultrasound outcomes and shear wave speed measured in the right lobe of the liver in adults with known or suspected non-alcoholic fatty liver disease,” Eur. Radiol., vol. 28, no. 12, pp. 4992–5000, 2018.
  • A. Han, M. P. Andre, L. Deiranieh, E. Housman, J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and W. D. O’Brien, Jr., “Repeatability and reproducibility of the ultrasonic attenuation coefficient and backscatter coefficient measured in the right lobe of the liver in adults with known or suspected nonalcoholic fatty liver disease,” J. Ultrasound Med., vol. 37, no. 8, pp. 1913–1927, 2018.
  • A. Han, “A method for stereological determination of the structure function from histological sections of isotropic scattering media,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 65, no. 6, pp. 1007–1016, 2018.
  • P. Muleki-Seya, A. Han, M. P. Andre, J. W. Erdman, and W. D. O’Brien, Jr., “Analysis of two quantitative ultrasound approaches,” Ultrason. Imaging, vol. 40, no. 2, pp. 84–96, 2018.
  • Y. Zhu, A. Han, W. D. O’Brien, Jr., M. L. Oelze, and M. F. Insana, “Limitations on estimation of effective scatterer diameters,” J. Acoust. Soc. Am., vol. 142, no. 6, pp. 3677–3690, 2017.
  • A. G. B. Cruz, A. Han, E. J. Roy, A. B. Guzmán, R. J. Miller, E. A. Driskell, W. D. O’Brien, Jr., and J. L. Shisler, “Deletion of the K1L gene results in a vaccinia virus that is less pathogenic due to muted innate immune responses, yet still elicits protective immunity,” J. Virol., vol. 91, no. 15, pp. e00542--17, 2017.
  • J. S. Paige, G. S. Bernstein, E. Heba, E. A. C. Costa, M. Fereirra, T. Wolfson, A. C. Gamst, M. A. Valasek, G. Y. Lin, A. Han, J. W. Erdman, Jr., W. D. O’Brien, Jr., M. P. Andre, R. Loomba, and C. B. Sirlin, “A pilot comparative study of quantitative ultrasound, conventional ultrasound, and MRI for predicting histology-determined steatosis grade in adult nonalcoholic fatty liver disease,” Am. J. Roentgenol., vol. 208, no. 5, pp. W168–W177, 2017.
  • A. Han, M. P. Andre, J. W. Erdman, Jr., R. Loomba, C. B. Sirlin, and W. D. O’Brien, Jr., “Repeatability and reproducibility of a clinically based QUS phantom study and methodologies,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 64, no. 1, pp. 218–231, 2017.
  • A. Han and W. D. O’Brien, Jr., “Structure function estimated from histological tissue sections,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 63, no. 9, pp. 1296–1305, 2016.
  • J. Garcia-Duitama, B. Chayer, A. Han, D. Garcia, M. L. Oelze, and G. Cloutier, “Experimental application of ultrafast imaging to spectral tissue characterization,” Ultrasound Med. Biol., vol. 41, no. 9, pp. 2506–2519, 2015.
  • S. C. Lin, E. Heba, T. Wolfson, B. Ang, A. Gamst, A. Han, J. W. Erdman, Jr., W. D. O’Brien, Jr., M. P. Andre, C. B. Sirlin, and R. Loomba, “Noninvasive diagnosis of nonalcoholic fatty liver disease and quantification of liver fat using a new quantitative ultrasound technique,” Clin. Gastroenterol. Hepatol., vol. 13, no. 7, pp. 1337–1345, 2015
  • A. Han and W. D. O’Brien, Jr., “Structure function for high-concentration biophantoms of polydisperse scatterer sizes,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control, vol. 62, no. 2, pp. 303–318, 2015.
  • A. Han, R. Abuhabsah, R. J. Miller, S. Sarwate, and W. D. O’Brien, Jr., “The measurement of ultrasound backscattering from cell pellet biophantoms and tumors ex vivo,” J. Acoust. Soc. Am., vol. 134, no. 1, pp. 686–693, 2013.
  • A. Han, R. Abuhabsah, J. P. Blue, Jr., S. Sarwate, and W. D. O’Brien, Jr., “Ultrasonic backscatter coefficient quantitative estimates from high-concentration Chinese hamster ovary cell pellet biophantoms,” J. Acoust. Soc. Am., vol. 130, no. 6, pp. 4139–4147, 2011.
  • M. Teisseire, A. Han, R. Abuhabsah, J. P. Blue, Jr., S. Sarwate, and W. D. O’Brien, Jr., “Ultrasonic backscatter coefficient quantitative estimates from Chinese hamster ovary cell pellet biophantoms,” J. Acoust. Soc. Am., vol. 128, no. 5, pp. 3175–3180, 2010.

Articles in Conference Proceedings

  • R. J. Miller, A. Han, J. W. Erdman, Jr., J. L. Shisler, M. A. Wallig, and W. D. O’Brien, Jr., “Quantitative ultrasound and the pancreas: Demonstration of early detection capability,” in 2017 IEEE Int. Ultrason. Symp. (IUS), 2017, pp. 1–4.
  • P. Muleki-Seya, A. Han, M. P. Andre, J. W. Erdman, Jr., and W. D. O’Brien, Jr., “Comparison of quantitative ultrasound parameters for fat content liver detection and monitoring,” in 2017 IEEE Int. Ultrason. Symp. (IUS), 2017, pp. 1–4.
  • A. Han and W. D. O’Brien, Jr., “Structure function: Theory, ultrasonic measurement, and histology,” in IEEE Int. Ultrason. Symp. (IUS), 2015, pp. 1–4.
  • A. Han, J. W. Erdman, Jr., D. G. Simpson, M. P. Andre, and W. D. O’Brien, Jr., “Early detection of fatty liver disease in mice via quantitative ultrasound,” in 2014 IEEE Int. Ultrason. Symp. (IUS), 2014, pp. 2363–2366.
  • M. P. Andre, A. Han, E. Heba, J. Hooker, R. Loomba, C. B. Sirlin, J. W. Erdman, Jr., and W. D. O’Brien, Jr., “Accurate diagnosis of non-alcoholic fatty liver disease in humans via quantitative ultrasound,” in 2014 IEEE Int. Ultrason. Symp. (IUS), 2014, pp. 2375–2377.
  • J. Garcia-Duitama, A. Han, B. Chayer, D. Garcia, M. L. Oelze, and G. Cloutier, “Experimental validation of plane wave imaging using k-space beamforming for spectral characterization of isotropic media,” 2014 IEEE Int. Ultrason. Symp. (IUS), 2014, pp. 2414–2417.
  • W. D. O’Brien, Jr., A. Han, and T. Auger, “Quantitative ultrasound from single cells to biophantoms to tumors,” in Conf. Proc. IEEE Eng. Med. Biol. Soc. (EMBS), 2012, pp. 1118–1120.

Professional Societies

  • IEEE Ultrasonics, Ferroelectrics, and Frequency Control Society (UFFC) (2015–Present)
  • Institute of Electrical and Electronics Engineers (IEEE) (2015–Present)
  • American Institute of Ultrasound in Medicine (AIUM) (2014–Present)
  • Acoustical Society of America (ASA) (2015–Present)

Research Honors

  • AIUM New Investigator Award in Basic Science (First place) (2016)
  • Young Investigator Travel Grant, 175th Meeting of Acoustical Society of America, Minneapolis (2018)

Courses Taught

  • BIOE 571 - Biological Measurement I
  • ECE 313 - Probability with Engrg Applic