Michael Insana

For more information

• Prof. Insana's Ultrasonic Imaging web page

Education

• Ph.D. Medical Physics, University of Wisconsin, Madison 1983

Professional Registrations

• Biomedical Engineering Society, 2008 - 2021

Teaching Statement

Graduate course BIOE 504 "Analytic Methods for Bioengineering" is a core course taken by all bioengineering graduate students. The goal is to review mathematical and computation methods applied to biological systems design and evaluation. It includes linear systems, probability, random processes, differential equations, control systems, and data modeling.

Undergraduate course BIOE 198 "Bioemedical Data Analysis" is an introduction to computing, statistics, and data management based in Matlab.

Resident Instruction

• BIOE 483 - Biomedical Computed Imaging Systems - 2021
• BIOE 198 - Data Analytics (UIUC) - 2018 to present
• BIOE 504 - Analytical Methods in Bioengineering (UIUC) - 2006 to present

Research Statement

Laboratory research focuses on the development of novel ultrasonic instrumentation and methods for imaging soft tissue microstructure, viscoelasticity and blood flow. The goal is to understand basic mechanisms of cancerous lesion formation, metastatic progression, responses to therapy, and sources of image contrast. Research includes the fundamentals of imaging system design and performance evaluation, signal processing, detection and estimation. The lab uses polymer hydrogels to develop models of visco- and poroelastic behavior of soft tissues for cancer imaging. Insana's lab also investigates spatio-temporal filtering for noise reduction and enhanced spatial resolution with applications in breast elasticity imaging and arterial-wall shear-stress estimation.

Graduate Research Opportunities

I now supervise 4 graduate students.

Research Interests

• Medical imaging systems development particularly for applications breast cancer, vascular disease, and kidney disease. Ultrasonics, signal processing, signal detection, elasticity imaging, soft tissue biomechanics, polymer mechanics, complex system modeling.

Research Topics

• Bioelectronics and Bioinformatics
• Data/Information Science and Systems
• Decision science
• Imaging science and systems
• Machine learning
• Medical imaging

Books Authored or Co-Authored (Original Editions)

• Michael F. Insana, "Biomedical Measurement and Data Science," Cambridge University Press, UK, 2021.
• Jamshid Ghaboussi and Michael F. Insana, "Understanding Systems: A Grand Challenge for 21st Century Engineering," World Scientific Publishing, Singapore, 2017.

Books Edited or Co-Edited (Original Editions)

• M.F. Insana and S.A. Wickline (editors), Proceedings of the IEEE, Volume 96, No. 3, Special Issue: "Multimodality Biomolecular Imaging", March Issue 2008.

Selected Articles in Journals

• Wang Y, Ghaboussi J, Hoerig C, Insana MF, “A data-driven approach to characterizing nonlinear elastic behavior of soft materials,” J Mechan Behav Biomed Materials, (in press).
• Kalyanam S, Toohey KS, Insana MF, “Modeling biphasic hydrogels under spherical indentation: application to soft tissues,” Mechanics of Materials, 161: 103987, 2021.
• Zhang H, Lu T, Zhang Q, Zhou Y, Zhu H, Harms J, Yang X, Wan M, Insana M.F., Solutions to ramp-hold dynamic oscillation indentation tests for assessing the viscoelasticity of hydrogel by Kelvin-Voigt fractional derivative modeling, Mech. Mater., 148, 103431, 2020.
• Bayat M, Nabavizadeh A, Nayak R, Webb JM, Gregory AV, Meixner DD, Fazzio RT. Insana MF, Alizad A, Fatemi M, Multi-parameter sub-Hertz analysis of viscoelasticity with quality metrics for differentiation of breast masses, Ultrasound Med Biol., 46(12):3393-3403, 2020.
• Hedhli J, Kim M, Knox HJ, Cole JA, Huynh T, Schuelke M, Dobrucki IT, Kalinowski L, Chan J, Sinusas AJ, Insana MF, Dobrucki LW, Imaging the landmarks of vascular recovery, Theranostics, 10(4):1733-1745, 2020.
• Hoerig C, Ghaboussi J, Insana MF, Data-driven elasticity imaging using Cartesian neural network constitutive models and the autoprogressive method, IEEE Trans Med Imaging 38(5):1150-1160, 2019.
• Kim M-W, Zhu Y, Hedhli J, Dobrucki LW, Insana MF, Multi-dimensional clutter filter optimization for ultrasonic perfusion imaging, IEEE Trans Ultrason Ferroelec Freq Control, 65(11): 2020-2029, 2018.
• Bayat M, Nabavizadeh A, Kumar V, Gregory A, Kinnick RR, Meixner D, Insana M, Alizad A, Fatemi M, Automated in vivo sub-Hertz analysis of viscoelasticity (SAVE) for evaluation of breast lesions, IEEE Trans Biomed Eng, 65(10): 2237-2247, 2018.
• Zhang H-M, Zhang Q, Ruan L, Duan J, Wan M, Insana MF, Modeling ramp-hold indentation measurements based on Kelvin-Voigt fractional derivative model, Meas Sci Technol, 29(3):035701, 2018.
• Zhu Y, Han A, O'Brien Jr. WD, Oelze ML, Insana MF, Analysis of scatterer size estimation using ultrasonic backscatter. J Acoust Soc Am, 142(6):3677-3690, 2017.
• Kim M-W, Abbey CK, Hedhli J, Dobrucki WL, Insana MF: Expanding acquisition and clutter filter dimensions for improved perfusion sensitivity, IEEE Trans Ultrason Ferroelec Freq Control, 64(10), 1429-1438, 2017
• Abbey CK, Zhu Y, Bahramian S, Insana MF: Linear system models for ultrasonic imaging: intensity signal statistics, IEEE Trans Ultrason Ferroelec Freq Control, 64(4): 669-678, 2017.
• Zhang H, Wang Y, Fatemi M, Insana MF: Assessing composition and structure of soft biphasic media from Kelvin-Voigt fractional derivative model parameters, Meas Sci Technol, 28 035703 (12pp), 2017.
• Nguyen NQ, Prager R, Insana MF: Improvements to ultrasonic beamformer design and implementation derived from the task-based analytical framework, J. Acoust Soc Am, 141 (6), 4427-4437, 2017.
• Zhang H, Wang Y, Insana MF: Ramp-hold relaxation solutions for the KVFD model applied to soft viscoelastic media, Meas Sci Technol, 27(2):025702 (11 pages), 2016.
• Nguyen NQ, Prager R, Insana MF: A task-based analytical framework for ultrasonic beamformer comparison, J Acoust Soc Am, 140(2): 1048-1059, 2016.
• Altahhan KN, Wang Y, Sobh N, Insana MF: Indentation measurements to validate dynamic elasticity imaging methods, Ultrasonic Imaging, 2015 Sep 16. pii: 0161734615605046.
• Qayyum M, Kwak JT, Insana MF: Stromal-epithelial responses to fractionated radiotherapy in a breast cancer microenvironment,” Cancer Cell International, 15:67, 2015. DOI:10.1186/s12935-015-0218-9.
• Wang Y, Insana MF: Viscoelastic properties of rodent mammary tumors using ultrasonic shear wave imaging, Ultrasonic Imaging 35(2):126-145, 2013
• Abbey CK, Nguyen NQ, Insana MF: Effects of frequency and bandwidth on diagnostic information transfer in ultrasonic B-mode imaging, IEEE Trans Ultrason Ferro Freq Control, 59(6):1115-1126, 2012
• Qayyum M, Insana MF: Stromal responses to fractionated radiotherapy, Internat J Rad Biol, 88(5):383-392, 2012 
• Coussot, C, Kalyanam, S, Yapp RD, Insana, MF, "Fractional derivative models for ultrasonic characterization of polymer and breast tissue viscoelasticity," IEEE Trans Ultrason Ferro Freq Contrl 56:715-26, 2009.
• Yapp RD, Insana MF, "pH-induced contrast in viscoelasticity imaging of biopolymers," Phys Med Biol 54:1089-1109, 2009.
• Qiu Y, Sridhar M, Tsou JK, Lindfors KK, Insana MF, "Ultrasonic viscoelasticity imaging of nonpalpable breast tumors: preliminary results," Academic Radiol, 15:1526-33, 2008.
• Insana MF, Wickline SA, "Multimodality biomolecular imaging," , Proc IEEE, vol 96, pp 378-81, 2008.
• Tsou JK, Gower RM, Ting HJ, Schaff UY, Insana MF, Passerini AG, Simon SI, "Spatial regulation of inflammation by human aortic endothelial cells in a linear gradient of shear stress," Microcirculation 15:311-23, 2008.
• Tsou JK, Simon SI, Barakat AI, Insana MF, "Role of ultrasonic shear rate estimation errors in assessing inflammatory response and vascular risk," Ultrasound Med Biol, 34: 963-972, 2008.

Articles in Conference Proceedings

• Dai B, Babaei S, Abbey CK, Insana MF, “Registration methods in power Doppler ultrasound for peripheral perfusion imaging,” SPIE Medical Imaging, MI-108. 15 pages. San Diego CA, February 20-24, 2022.
• Zhou Y, Wang K, Zhang K, Wan M, Fatemi M, Insana MF, Zhang H, “Deep reinforcement learning of KVFD viscoelastic imaging parameters,” Proc IEEE Ultrasonics Symposium, 4 pages, Xi’an, China (virtual) September 12-16, 2021.
• Insana MF, "Statistical ultrasonics: the influence of Robert F. Wagner," Proc SPIE Medical Imaging: Image Perception, Observer Performance, and Technology Assessment, vol. 7263, pp. 72630E1-6, 2009.

Journal Editorships

• Editor-in-Chief, IEEE Trans Medical Imaging (2015-2020).

Service on Department Committees

• Interim Department Head, Bioengineering (2008-2010)

Honors

• Life Fellow of the IEEE - 2020 (2020)
• Fellow of the Acoustical Society of America - 2009
• Fellow of the Institute of Physics - 1999

Recent Courses Taught

• BIOE 198 MI - Biomedical Data Analysis
• BIOE 210 - Linear Alg for Biomed Data Sci
• BIOE 483 - Biomedical Imaging Physics & S
• BIOE 497 MFI (BIOE 497 MI, BIOE 497 MI2) - Individual Study
• BIOE 504 - Analytical Methods in Bioeng